“Is it a boy or a girl?”- This is typically the first question asked of new parents, and often a defining aspect of individual identity. But what is the brain biology behind sexual differences? Join Bridget Nugent, a researcher from the University of Pennsylvania, to learn about how sex differences in the embryonic brain are created by hormones and influenced by epigenetics as the brain develops and matures.
- An overview of the epigenetic processes, and how they relate to sexual differentiation of the brain.
- A seminal paper describing the discovery of how gonadal steroid hormones (testosterone) “organize” sex differences in the developing brain.
- In this physiology review, learn how Estradiol exposure during the “sensitive period”, a brief window of time when the brain is vulnerable to the organizing effects of gonadal hormones, changes the developing male brain in many ways.
- Read about the most recent results that suggest sexual differentiation of the brain is more flexible than we once believed.
About the Speaker
Dr. Bridget Nugent received her PhD from the University of Maryland School of Medicine. Her award-winning dissertation revealed a novel role of DNA methylation in feminization of the brain. She continued her research on the neuroendocrine origins of behavioral plasticity as a Donnelly Fellow at the Yale Institute for Biospheric studies, where she investigated the hormonal and neurogenomic mechanisms of phenotypic plasticity in wild Mediterranean reef fish. She is currently a Postdoctoral Researcher in the Department of Biomedical Sciences at the University of Pennsylvania, where she studies prenatal stress and sex-specific epigenetic mechanisms that underlie gender biases in the etiology of neurodevelopmental disorders.
The SciCafe Series is proudly sponsored by Judy and Josh Weston.