Can the Hyperdisease Hypothesis be falsified?

MacPhee and Marx do suggest a way in which the hypothesis could be falsified by empirical evidence. Supposing that the mass die-offs at the end of the Pleistocene were caused by diseases. Would it be possible to search for those pathogens using the scientific tools of molecular biology? Recently, there have been a number of successful extractions of DNA from permafrost mammoths, a Neanderthal human, and other Quaternary fossils. Would it be possible to devise methods to look for microbes in fossils and, if so, to determine their identity? MacPhee and Marx think so, and have started to examine the tissues of Siberian mammoths in an effort to look for the elusive killer plague they imagine to have been responsible for the extinction of Mammuthus primigenius. Closer to the present, they are also looking at the remains of mammal species that have died out in the last hundred years or so, to see whether any of these extinctions might have been prompted by emerging diseases.