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On September 30, 2010, a NASA space telescope called the Wide-field Infrared Survey Explorer, or WISE, completed its sweeping goal: to record observations of the entire sky in infrared light. The WISE science team is now sifting through the telescope's two million images to spot objects that no astronomer has ever seen before. WISE's most intriguing finds will include mysterious objects called brown dwarfs, blacker-than-coal asteroids, and the Universe's brightest galaxies. All told, WISE's data will yield a new picture of the Universe, from our local region to the remotest reaches, and from the distant past to the present. In this Astro Bulletin, watch the WISE team launch and focus this unique eye on the sky.