Hi Thomas,
It depends. First let's look at the reasons that ecosystems can become destroyed.
There are several things that can happen within an ecosystem that can change it. For example, a forest fire will significantly change the plant and animal communities that live there. Organisms from flowers to insects to large mammals will be affected.
Actions from outside the ecosystem can also affect it. For example, fertilizer runoff from a farm field can pollute a stream or a pond that's downstream.
When the actions that change and degrade ecosystems are widespread and intense, they can destroy an ecosystem. You can imagine how this might be possible for a small pond, but large ecosystems can be destroyed too.