The challenges of eliminating devastating diseases are enormous, but successful strategies can bring about colossal social and economic benefits. Countdown to Zero, a new exhibition about scientific and social innovations that are ridding the world of ancient afflictions, will open at the American Museum of Natural History on January 13, 2015. The exhibition, developed in collaboration with The Carter Center, focuses on several global efforts that have been able to contain, eliminate, or eradicate disease. Chief among these is the 30-year campaign that may soon eradicate Guinea worm disease, positioning it to become only the second human disease ever eradicated, after smallpox. The exhibition also highlights the ongoing programs to eliminate polio and prospects for more localized elimination of river blindness, lymphatic filariasis, and malaria.